Deferasirox (Exjade®, ICL670): A Journey into Labile Iron Centers of Living Cardiomyocytes.

Keyphrases

• Cardiomyocytes 100%
• Labile Iron 100%
• ICL670 100%
• Exjade 100%
• Deferasirox 100%
• Chelator 62%
• Chelates 37%
• Deferoxamine 37%
• Iron Pools 37%
• Reactive Oxidant Species 37%
• Mitochondria 25%
• Drug Concentration 25%
• Iron Overload 25%
• Plasma Parameters 25%
• Serum-containing Medium 25%
• Species Formation 25%
• Lipophilic 12%
• Cellular Compartments 12%
• Incubation 12%
• Liver 12%
• Albumin 12%
• Incubation Time 12%
• Fe Chelate 12%
• Daily Dose 12%
• Iron Toxicity 12%
• Culture Media 12%
• Iron Chelation 12%
• Specific Peptide 12%
• Intracellular Compartments 12%
• Bovine Serum Albumin 12%
• Targeted Sequencing 12%
• Neonatal Rats 12%
• Iron Extraction 12%
• Serum-free Medium 12%
• Cell Organelles 12%
• Chelation 12%
• Free Drug 12%
• Cmax 12%
• Fluorescence Microscopy Imaging 12%
• Ferric Ammonium Citrate 12%
• 59Fe 12%
• Fetal Calf Serum 12%
• In Vivo Fluorescence 12%
• Tracing Studies 12%
• Metal Sensor 12%
• Iron Sensor 12%
• H9c2 Cells 12%
• Oral Iron Chelator 12%
• Drug Intake 12%
• Iron Retention 12%
• Labile Plasma Iron 12%
• Endocrine Glands 12%

Biochemistry, Genetics and Molecular Biology

• Cardiac Muscle Cell 100%
• Mitochondrion 50%
• Drug Concentration 50%
• Iron Poisoning 50%
• Iron Overload 50%
• Minimum Plasma Concentration 50%
• Blood Plasma 50%
• Incubation Time 25%
• Chelation 25%
• Bovine Serum Albumin 25%
• Fluorescence Microscopy 25%
• Iron Chelation 25%
• Serum Iron 25%
• Maximum Concentration 25%
• Target Peptide 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Deferasirox 100%
• Chelating Agent 50%
• Oxidizing Agent 30%
• Deferoxamine 30%
• Iron Poisoning 20%
• Drug Concentration 20%
• Incubation Time 10%
• Iron Chelating Agent 10%
• Bovine Serum Albumin 10%
• Iron 10%
• Fluorescence Microscopy 10%
• Iron 59 10%
• Ferric Ammonium Citrate 10%