Defining essential genes for human pluripotent stem cells by CRISPR-Cas9 screening in haploid cells

Keyphrases

• Human Pluripotent Stem Cells (hPSCs) 100%
• CRISPR-Cas9 Screen 100%
• Haploid Cells 100%
• Loss Function 33%
• Transcription Factor 16%
• Cellular Compartments 16%
• Growth Retardation 16%
• Protein-coding Genes 16%
• Tumor Suppressor Gene 16%
• Autosomal Recessive 16%
• Early Embryonic Development 16%
• DNA Repair 16%
• Nuclear Factor 16%
• Pluripotency 16%
• Function Library 16%
• Normal Growth 16%
• Growth Advantage 16%
• Coordinated Expression 16%
• MTOR Pathway 16%
• Human Pluripotency 16%
• Intrinsic Bias 16%

Biochemistry, Genetics and Molecular Biology

• Stem Cell 100%
• CRISPR/Cas9 100%
• Essential Gene 100%
• Transcription Factors 16%
• Embryogenesis 16%
• P53 16%
• Tumor Suppressor Gene 16%
• Cell Cycle 16%
• DNA Repair 16%
• Mammalian Target of Rapamycin 16%
• Autosomal Recessive Disorder 16%