Defining Human Pluripotency

Atilgan Yilmaz, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Human pluripotent stem cells harbor the capacity to differentiate into cells from the three embryonic germ layers, and this ability grants them a central role in modeling human disorders and in the field of regenerative medicine. Here, we review pluripotency in human cells with respect to four different aspects: (1) embryonic development, (2) transcriptomes of pluripotent cell stages, (3) genes and pathways that reprogram somatic cells into pluripotent stem cells, and finally (4) the recent identification of the human pluripotent stem cell essentialome. These four aspects of pluripotency collectively culminate in a broader understanding of what makes a cell pluripotent.

Original languageAmerican English
Pages (from-to)9-22
Number of pages14
JournalCell Stem Cell
Issue number1
StatePublished - 3 Jul 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc.


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