TY - JOUR
T1 - Defining myeloid-derived suppressor cells
AU - Akkari, Leila
AU - Amit, Ido
AU - Bronte, Vincenzo
AU - Fridlender, Zvi G.
AU - Gabrilovich, Dmitry I.
AU - Ginhoux, Florent
AU - Hedrick, Catherine C.
AU - Ostrand-Rosenberg, Suzanne
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2024/12
Y1 - 2024/12
N2 - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.
AB - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.
UR - http://www.scopus.com/inward/record.url?scp=85197683226&partnerID=8YFLogxK
U2 - 10.1038/s41577-024-01062-0
DO - 10.1038/s41577-024-01062-0
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C2 - 38969773
AN - SCOPUS:85197683226
SN - 1474-1733
VL - 24
SP - 850
EP - 857
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 12
ER -
