Defining myeloid-derived suppressor cells

Leila Akkari; Ido Amit; Vincenzo Bronte; Zvi G. Fridlender; Dmitry I. Gabrilovich; Florent Ginhoux; Catherine C. Hedrick; Suzanne Ostrand-Rosenberg

doi:10.1038/s41577-024-01062-0

Defining myeloid-derived suppressor cells

Leila Akkari^*
, Ido Amit^*
, Vincenzo Bronte^*
, Zvi G. Fridlender^*
, Dmitry I. Gabrilovich^*
, Florent Ginhoux^*
, Catherine C. Hedrick^*
, Suzanne Ostrand-Rosenberg^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

Original language	English
Pages (from-to)	850-857
Number of pages	8
Journal	Nature Reviews Immunology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1038/s41577-024-01062-0
State	Published - Dec 2024

Bibliographical note

Publisher Copyright:
© Springer Nature Limited 2024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/s41577-024-01062-0

Cite this

@article{fb6f70eb90fd42809c9e0636b6eeac25,

title = "Defining myeloid-derived suppressor cells",

abstract = "Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.",

author = "Leila Akkari and Ido Amit and Vincenzo Bronte and Fridlender, \{Zvi G.\} and Gabrilovich, \{Dmitry I.\} and Florent Ginhoux and Hedrick, \{Catherine C.\} and Suzanne Ostrand-Rosenberg",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41577-024-01062-0",

language = "אנגלית",

volume = "24",

pages = "850--857",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Research",

number = "12",

}

TY - JOUR

T1 - Defining myeloid-derived suppressor cells

AU - Akkari, Leila

AU - Amit, Ido

AU - Bronte, Vincenzo

AU - Fridlender, Zvi G.

AU - Gabrilovich, Dmitry I.

AU - Ginhoux, Florent

AU - Hedrick, Catherine C.

AU - Ostrand-Rosenberg, Suzanne

PY - 2024/12

Y1 - 2024/12

N2 - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

AB - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

UR - https://www.scopus.com/pages/publications/85197683226

U2 - 10.1038/s41577-024-01062-0

DO - 10.1038/s41577-024-01062-0

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 38969773

AN - SCOPUS:85197683226

SN - 1474-1733

VL - 24

SP - 850

EP - 857

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 12

ER -

Defining myeloid-derived suppressor cells

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this