Abstract
Dehydroepiandrosterone (DHEA) is a native steroid with an immunomodulating activity. Recently it was suggested that its age-associated decline is related with immunosenescence. To examine whether DHEA administration could effectively reverse the age-associated decline of immunity against influenza vaccine, aged mice were simultaneously vaccinated and treated with DHEA. Reversal of the age-associated decline and a significant constant increase of humoral response was observed in treated mice. Increased resistance to post-vaccination intranasal challenge with live influenza virus was observed in DHEA-treated aged mice. Thus, DHEA treatment overcame the age-related defect in the immunity of old mice against influenza.
Original language | English |
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Pages (from-to) | 1445-1448 |
Number of pages | 4 |
Journal | Vaccine |
Volume | 13 |
Issue number | 15 |
DOIs | |
State | Published - 1995 |
Keywords
- Dehydroepiandrosterone
- immunosenescence
- influenza vaccine