Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection

H. D. Danenberg*, A. Ben-Yehuda, Z. Zakay-Rones, G. Friedman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Dehydroepiandrosterone (DHEA) is a native steroid with an immunomodulating activity. Recently it was suggested that its age-associated decline is related with immunosenescence. To examine whether DHEA administration could effectively reverse the age-associated decline of immunity against influenza vaccine, aged mice were simultaneously vaccinated and treated with DHEA. Reversal of the age-associated decline and a significant constant increase of humoral response was observed in treated mice. Increased resistance to post-vaccination intranasal challenge with live influenza virus was observed in DHEA-treated aged mice. Thus, DHEA treatment overcame the age-related defect in the immunity of old mice against influenza.

Original languageEnglish
Pages (from-to)1445-1448
Number of pages4
JournalVaccine
Volume13
Issue number15
DOIs
StatePublished - 1995

Keywords

  • Dehydroepiandrosterone
  • immunosenescence
  • influenza vaccine

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