Demonstration of a ouabainlike plasma compound in hypertension prone and hypertension resistant rats

David Lichtstein*, Dahlia Minc, Yakhin Shimoni, Joseph Deutsch, Judith Mekler, Drori Ben-Ishay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Material extracted and partially purified from plasma of the Sabra hypertension prone rats was found to be capable of 1) inhibiting the binding of 3H-ouabain to rat brain synaptosomes, 2) inhibiting the activity of rat brain microsomal Na, K activated adenosine triphosphatase, and 3) increasing the contractile force of rat heart muscle. The results demonstrate the presence of a ouabainlike compound in the plasma of these rats. The plasma concentration of this compound in Sabra hypertension prone rats was 698 ± 199 nmol/ml in ouabain equivalents (SKM; n = 11) versus 2543 ± 1140 nmol/ml (n = 9) in the Sabra normotensive strain. The presence of ouabainlike compound in the plasma is consistent with the hypothesis that this compound functions as a hormone that regulates Na, K activated adenosine triphosphatase activity and the physiological processes in which this enzyme is involved.

Original languageEnglish
Pages (from-to)729-733
Number of pages5
JournalHypertension
Volume7
Issue number5
DOIs
StatePublished - 1985

Keywords

  • Digitalis
  • Genetic hypertensive rats
  • Heart contractility
  • Na, K activated adenosine triphosphatase
  • Ouabainlike compounds

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