Abstract
Material extracted and partially purified from plasma of the Sabra hypertension prone rats was found to be capable of 1) inhibiting the binding of 3H-ouabain to rat brain synaptosomes, 2) inhibiting the activity of rat brain microsomal Na, K activated adenosine triphosphatase, and 3) increasing the contractile force of rat heart muscle. The results demonstrate the presence of a ouabainlike compound in the plasma of these rats. The plasma concentration of this compound in Sabra hypertension prone rats was 698 ± 199 nmol/ml in ouabain equivalents (SKM; n = 11) versus 2543 ± 1140 nmol/ml (n = 9) in the Sabra normotensive strain. The presence of ouabainlike compound in the plasma is consistent with the hypothesis that this compound functions as a hormone that regulates Na, K activated adenosine triphosphatase activity and the physiological processes in which this enzyme is involved.
Original language | English |
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Pages (from-to) | 729-733 |
Number of pages | 5 |
Journal | Hypertension |
Volume | 7 |
Issue number | 5 |
DOIs | |
State | Published - 1985 |
Keywords
- Digitalis
- Genetic hypertensive rats
- Heart contractility
- Na, K activated adenosine triphosphatase
- Ouabainlike compounds