Demonstration of serum antiplatelet antibodies in experimental acute canine ehrlichiosis

Trevor Waner*, Shimon Harrus, Douglas J. Weiss, Hylton Bark, Avi Keysary

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

This report presents evidence for the presence of antiplatelet antibodies in sera of dogs experimentally infected with Ehrlichia canis, during the acute phase of the disease. Six healthy adult male beagle dogs were inoculated intravenously with blood from a longstanding infected dog with the Israel strain 611 of E. canis. Thrombocytopenia and concurrent increase in mean platelet volume were the most consistent haematological signs of the disease. The dogs developed an antibody titre to E. canis from Day 15 postinoculation. All dogs were antiplatelet antibody negative before inoculation. Twenty-four days postinoculation with E. canis, when the platelet count was at its lowest, antibodies to platelets were demonstrated, in the sera of five of the six dogs.

Original languageAmerican English
Pages (from-to)177-182
Number of pages6
JournalVeterinary Immunology and Immunopathology
Volume48
Issue number1-2
DOIs
StatePublished - Sep 1995

Keywords

  • Antiplatelet antibodies
  • Ehrlichia canis
  • Pathogenesis
  • Thrombocytopenia

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