Dendritic cells and their role in periodontal disease

A. Wilensky, H. Segev, G. Mizraji, Y. Shaul, T. Capucha, M. Shacham, A. H. Hovav*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

T cells, particularly CD4+ T cells, play a central role in both progression and control of periodontal disease, whereas the contribution of the various CD4+ T helper subsets to periodontal destruction remains controversial, the activation, and regulation of these cells is orchestrated by dendritic cells. As sentinels of the oral mucosa, dendritic cells encounter and capture oral microbes, then migrate to the lymph node where they regulate the differentiation of CD4+ T cells. It is thus clear that dendritic cells are of major importance in the course of periodontitis, as they hold the immunological cues delivered by the pathogen and the surrounding environment, allowing them to induce destructive immunity. In recent years, advanced immunological techniques and new mouse models have facilitated in vivo studies that have provided new insights into the developmental and functional aspects of dendritic cells. This progress has also benefited the characterization of oral dendritic cells, as well as to their function in periodontitis. Here, we provide an overview of the various gingival dendritic cell subsets and their distribution, while focusing on their role in periodontal bone loss.

Original languageAmerican English
Pages (from-to)119-126
Number of pages8
JournalOral Diseases
Volume20
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • Dendritic cells
  • Gingiva
  • Oral mucosa
  • Periodontitis
  • T cells

Fingerprint

Dive into the research topics of 'Dendritic cells and their role in periodontal disease'. Together they form a unique fingerprint.

Cite this