Dendritic cells, monocytes and macrophages: A unified nomenclature based on ontogeny

Martin Guilliams, Florent Ginhoux, Claudia Jakubzick, Shalin H. Naik, Nobuyuki Onai, Barbara U. Schraml, Elodie Segura, Roxane Tussiwand, Simon Yona

Research output: Contribution to journalReview articlepeer-review

1278 Scopus citations

Abstract

The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species.

Original languageAmerican English
Pages (from-to)571-578
Number of pages8
JournalNature Reviews Immunology
Volume14
Issue number8
DOIs
StatePublished - Aug 2014
Externally publishedYes

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