Dendritic development and plasticity of adult-born neurons in the mouse olfactory bulb

Adi Mizrahi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


The mammalian brain maintains few developmental niches where neurogenesis persists into adulthood. One niche is located in the olfactory system where the olfactory bulb continuously receives functional interneurons. In vivo two-photon microscopy of lentivirus-labeled newborn neurons was used to directly image their development and maintenance in the olfactory bulb. Time-lapse imaging of newborn neurons over several days showed that dendritic formation is highly dynamic with distinct differences between spiny neurons and non-spiny neurons. Once incorporated into the network, adult-born neurons maintain significant levels of structural dynamics. This structural plasticity is local, cumulative and sustained in neurons several months after their integration. Thus, I provide a new experimental system for directly studying the pool of regenerating neurons in the intact mammalian brain and suggest that regenerating neurons form a cellular substrate for continuous wiring plasticity in the olfactory bulb.

Original languageAmerican English
Pages (from-to)444-452
Number of pages9
JournalNature Neuroscience
Issue number4
StatePublished - Apr 2007

Bibliographical note

Funding Information:
I thank Y. Finelt for technical help and P. Mombaerts for the M71-GFP mice. I thank I. Segev, Y. Yarom, S. Wagner, I. Davison and members of my lab for critically reading early versions of the manuscript. Special thanks to S. Wagner for the intracellular labeling of PGNs. A.M. is supported by a Career Development Award from the International Human Frontier Science Program Organization and by ISF grant # 313–05.


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