TY - JOUR
T1 - DeoT, a DeoR-type transcriptional regulator of multiple target genes
AU - Elgrably-Weiss, Maya
AU - Schlosser-Silverman, Eliana
AU - Rosenshine, Ilan
AU - Altuvia, Shoshy
PY - 2006/1
Y1 - 2006/1
N2 - In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid β-oxidation and peptide degradation.
AB - In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid β-oxidation and peptide degradation.
KW - DeoR
KW - Global regulator
KW - Operon
KW - Repression
KW - Transcription control
KW - yciT
UR - http://www.scopus.com/inward/record.url?scp=33645093213&partnerID=8YFLogxK
U2 - 10.1111/j.1574-6968.2005.00020.x
DO - 10.1111/j.1574-6968.2005.00020.x
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C2 - 16451192
AN - SCOPUS:33645093213
SN - 0378-1097
VL - 254
SP - 141
EP - 148
JO - FEMS Microbiology Letters
JF - FEMS Microbiology Letters
IS - 1
ER -