DeoT, a DeoR-type transcriptional regulator of multiple target genes

Maya Elgrably-Weiss, Eliana Schlosser-Silverman, Ilan Rosenshine, Shoshy Altuvia*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid β-oxidation and peptide degradation.

Original languageAmerican English
Pages (from-to)141-148
Number of pages8
JournalFEMS Microbiology Letters
Volume254
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • DeoR
  • Global regulator
  • Operon
  • Repression
  • Transcription control
  • yciT

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