DeoT, a DeoR-type transcriptional regulator of multiple target genes

Maya Elgrably-Weiss; Eliana Schlosser-Silverman; Ilan Rosenshine; Shoshy Altuvia

doi:10.1111/j.1574-6968.2005.00020.x

DeoT, a DeoR-type transcriptional regulator of multiple target genes

Maya Elgrably-Weiss
, Eliana Schlosser-Silverman
, Ilan Rosenshine
, Shoshy Altuvia^*

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

In this study, we investigated the genetic organization and function of Escherichia coli yciT, a gene predicted by computational methods to belong to the DeoR-type family of transcriptional regulators. We show that transcription of yciT (here denoted deoT for deoR-Type) initiates from a promoter located upstream of a putative open reading frame (denoted deoL for deoT Leader). We also show that DeoT acts as a global regulator, repressing the expression of a number of genes involved in a variety of metabolic pathways including transport of maltose, fatty acid β-oxidation and peptide degradation.

Original language	English
Pages (from-to)	141-148
Number of pages	8
Journal	FEMS Microbiology Letters
Volume	254
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2005.00020.x
State	Published - Jan 2006

Keywords

DeoR
Global regulator
Operon
Repression
Transcription control
yciT

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10.1111/j.1574-6968.2005.00020.x

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DeoT, a DeoR-type transcriptional regulator of multiple target genes

Abstract

Keywords

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