Dependence of cortical plasticity on correlated activity of single neurons and on behavioral context

Ehud Ahissar*, Eilon Vaadia, Merav Ahissar, Hagai Bergman, Amos Arieli, Moshe Abeles

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

294 Scopus citations

Abstract

It has not been possible to analyze the cellular mechanisms underlying learning in behaving mammals because of the difficulties in recording intracellularly from awake animals. Therefore, in the present study of neuronal plasticity in behaving monkeys, the net effect of a single neuron on another neuron (the "functional connection") was evaluated by cross-correlating the times of firing of the two neurons. When two neurons were induced to fire together within a short time window, the functional connection between them was potentiated, and when simultaneous firing was prevented, the connection was depressed. These modifications were strongly dependent on the behavioral context of the stimuli that induced them. The results indicate that changes in the temporal contingency between neurons are often necessary, but not sufficient, for cortical plasticity in the adult monkey: behavioral relevance is required.

Original languageAmerican English
Pages (from-to)1412-1415
Number of pages4
JournalScience
Volume257
Issue number5075
StatePublished - 4 Sep 1992

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