Derivatives of L-pyrimidylalanine

Gury Zvilichovsky; Vadim Gurvich

doi:10.1039/a604879j

Derivatives of L-pyrimidylalanine

Gury Zvilichovsky^*, Vadim Gurvich

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Optically active derivatives of L-isoxazolo[2,3-a]pyrimidin-4-ylalanine are prepared by the combination of Birch reduction of the phenyl ring of L-phenylalanine, followed by ozonolysis and condensation with 3-amino-5-oxo-4-phenyl-2,5-dihydroisoxazole. Ring cleavage of the five-membered ring by reduction, oxidation and nucleophiles gives pyrimidylalanine derivatives.

Original language	English
Pages (from-to)	1069-1071
Number of pages	3
Journal	Journal of the Chemical Society, Perkin Transactions 1
Issue number	7
DOIs	https://doi.org/10.1039/a604879j
State	Published - 7 Apr 1997

Access to Document

10.1039/a604879j

Cite this

@article{acb8ce432c0c432e9d18d31f02c7c310,

title = "Derivatives of L-pyrimidylalanine",

abstract = "Optically active derivatives of L-isoxazolo[2,3-a]pyrimidin-4-ylalanine are prepared by the combination of Birch reduction of the phenyl ring of L-phenylalanine, followed by ozonolysis and condensation with 3-amino-5-oxo-4-phenyl-2,5-dihydroisoxazole. Ring cleavage of the five-membered ring by reduction, oxidation and nucleophiles gives pyrimidylalanine derivatives.",

author = "Gury Zvilichovsky and Vadim Gurvich",

year = "1997",

month = apr,

day = "7",

doi = "10.1039/a604879j",

language = "אנגלית",

pages = "1069--1071",

journal = "Journal of the Chemical Society, Perkin Transactions 1",

issn = "0300-922X",

publisher = "Chemical Society",

number = "7",

}

TY - JOUR

T1 - Derivatives of L-pyrimidylalanine

AU - Zvilichovsky, Gury

AU - Gurvich, Vadim

PY - 1997/4/7

Y1 - 1997/4/7

N2 - Optically active derivatives of L-isoxazolo[2,3-a]pyrimidin-4-ylalanine are prepared by the combination of Birch reduction of the phenyl ring of L-phenylalanine, followed by ozonolysis and condensation with 3-amino-5-oxo-4-phenyl-2,5-dihydroisoxazole. Ring cleavage of the five-membered ring by reduction, oxidation and nucleophiles gives pyrimidylalanine derivatives.

AB - Optically active derivatives of L-isoxazolo[2,3-a]pyrimidin-4-ylalanine are prepared by the combination of Birch reduction of the phenyl ring of L-phenylalanine, followed by ozonolysis and condensation with 3-amino-5-oxo-4-phenyl-2,5-dihydroisoxazole. Ring cleavage of the five-membered ring by reduction, oxidation and nucleophiles gives pyrimidylalanine derivatives.

UR - http://www.scopus.com/inward/record.url?scp=33748617589&partnerID=8YFLogxK

U2 - 10.1039/a604879j

DO - 10.1039/a604879j

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:33748617589

SN - 0300-922X

SP - 1069

EP - 1071

JO - Journal of the Chemical Society, Perkin Transactions 1

JF - Journal of the Chemical Society, Perkin Transactions 1

IS - 7

ER -

Derivatives of L-pyrimidylalanine

Abstract

Access to Document

Other files and links

Fingerprint

Cite this