Deriving physical connectivity from neuronal morphology

Nir Kalisman, Gilad Silberberg, Henry Markram*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


A model is presented that allows prediction of the probability for the formation of appositions between the axons and dendrites of any two neurons based only on their morphological statistics and relative separation. Statistics of axonal and dendritic morphologies of single neurons are obtained from 3D reconstructions of biocytin-filled cells, and a statistical representation of the same cell type is obtained by averaging across neurons according to the model. A simple mathematical formulation is applied to the axonal and dendritic statistical representations to yield the probability for close appositions. The model is validated by a mathematical proof and by comparison of predicted appositions made by layer 5 pyramidal neurons in the rat somatosensory cortex with real anatomical data. The model could be useful for studying microcircuit connectivity and for designing artificial neural networks.

Original languageAmerican English
Pages (from-to)210-218
Number of pages9
JournalBiological Cybernetics
Issue number3
StatePublished - Mar 2003
Externally publishedYes


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