Desensitization of normal rat kidney cells to adenosine

Michael E. Newman; Alexander Levitzki

doi:10.1016/0006-2952(83)90665-2

Desensitization of normal rat kidney cells to adenosine

Michael E. Newman^*
, Alexander Levitzki

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Membranes prepared from normal rat kidney fibroblasts possess an adenosine receptor of the stimulatory (A₂ or R_a) type linked to adenylate cyclase. Homologous desensitization to adenosine A₂ agonists is developed upon exposure of the cells to adenosine-NCC, a potent A₂ agonist. This desensitization process is followed by a heterologous desensitization which is manifested in a time-dependent reduction of 1-epinephrine and NaF-dependent adenylate cyclase.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Biochemical Pharmacology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/0006-2952(83)90665-2
State	Published - 1 Jan 1983

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title = "Desensitization of normal rat kidney cells to adenosine",

abstract = "Membranes prepared from normal rat kidney fibroblasts possess an adenosine receptor of the stimulatory (A2 or Ra) type linked to adenylate cyclase. Homologous desensitization to adenosine A2 agonists is developed upon exposure of the cells to adenosine-NCC, a potent A2 agonist. This desensitization process is followed by a heterologous desensitization which is manifested in a time-dependent reduction of 1-epinephrine and NaF-dependent adenylate cyclase.",

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AB - Membranes prepared from normal rat kidney fibroblasts possess an adenosine receptor of the stimulatory (A2 or Ra) type linked to adenylate cyclase. Homologous desensitization to adenosine A2 agonists is developed upon exposure of the cells to adenosine-NCC, a potent A2 agonist. This desensitization process is followed by a heterologous desensitization which is manifested in a time-dependent reduction of 1-epinephrine and NaF-dependent adenylate cyclase.

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Desensitization of normal rat kidney cells to adenosine

Abstract

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