Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity

Ido M. Herzog, Mark Feldman, Anat Eldar-Boock, Ronit Satchi-Fainaro, Micha Fridman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Tobramycin-based cationic amphiphiles differing in the chemical bond linking their hydrophobic and hydrophilic parts were synthesized and biologically evaluated. Several compounds demonstrated potent antimicrobial activities compared to the parent drug. One analogue exhibited a significant reduction in red blood cells hemolysis, demonstrating that it is possible to maintain the antimicrobial potency of these molecules while reducing their undesired hemolytic effect through chemical modifications.

Original languageAmerican English
Pages (from-to)120-124
Number of pages5
JournalMedChemComm
Volume4
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

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