Abstract
Several novel antioxidant-iron chelators bearing 8-hydroxyoxyquinoline moiety were synthesized, and various properties related to their iron chelation, and neuroprotective action were investigated. All the chelators exhibited strong iron(III) chelating and high antioxidant properties. Chelator 9 (HLA20), having good permeability into K562 cells and moderate selective MAO-B inhibitory activity (IC 50 110 μM), displayed the hightest protective effects against differentiated P19 cell death induced by 6-hydroxydopamine. EPR studies suggested that Chelator 9 also act as radical scavenger to directly scavenge hydroxyl radical.
Original language | English |
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Pages (from-to) | 773-783 |
Number of pages | 11 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - 1 Feb 2005 |
Keywords
- 8-Hydroxyquinoline
- Antioxidant-iron chelator
- Lipid peroxidation
- Neuroprotection