Designed Loop Extension Followed by Combinatorial Screening Confers High Specificity to a Broad Matrix Metalloproteinase Inhibitor

Keyphrases

• Matrix Metalloproteinases 100%
• High Specificity 100%
• Matrix Metalloproteinase Inhibitors 100%
• Combinatorial Screening 100%
• N-terminal Domain 80%
• TIMP-2 80%
• Matrix metalloproteinase-3 (MMP-3) 60%
• MMP14 60%
• Antitarget 40%
• Yeast Surface Display 20%
• Binding Affinity 20%
• Binding Specificity 20%
• New Interaction 20%
• Computational Design 20%
• Protein-ligand 20%
• Protein Engineering 20%
• Deep Sequencing Analysis 20%
• Multiple Sequence Alignment 20%
• Large Matrices 20%
• Experimental mutagenesis 20%
• Design Prediction 20%
• Design Screening 20%
• AlphaFold 20%
• Focused Library 20%
• Loop Design 20%
• Data Design 20%
• Nonconserved Residues 20%
• Protein Conservation 20%
• NGS Data 20%

Biochemistry, Genetics and Molecular Biology

• Matrix Metalloproteinase 100%
• Matrix Metalloproteinase Inhibitor 100%
• N-Terminus 36%
• Metalloprotease Inhibitor 36%
• Next Generation Sequencing 9%
• Binding Affinity 9%
• Mutagenesis 9%
• Deep Sequencing 9%
• Sequence Alignment 9%
• Protein Ligand 9%
• Protein Engineering 9%