Detecting and measuring higher order synchronization among neurons: A Bayesian Approach

Laura Martignon, Ame Schwarz, Kathryn Laskey, Eilon Vaadia

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A Bayesian approach to modeling and inferring patterns of synchronous activation in a group of neurons. A major objective of the research is to provide statistical tools for detecting changes in synchronization patterns. Our framework is not restricted to the case of correlated pairs, but generalizes the Boltzmann machine model to allow for higher order interactions. A Markov Chain Monte Carlo Model Composition (MC3) algorithm is applied in order to search over connectivity structures and uses Laplace's method to approximate their posterior probabilities.Performance of the method was first tested on synthetic data. The method was then applied to data obtained on multi-unit recordings of six neurons in the visual cortex of a rhesus monkey in two different attentional states. The obtained results indicate that the interaction structure predicted by the data is richer than just a set of synchronous pairs. They also confirmed the experimenter's conjecture that different attentional states were associated with different interaction structures.

Original languageEnglish
Title of host publicationArtificial Neural Networks, ICANN 1996 - 1996 International Conference, Proceedings
PublisherSpringer Verlag
Pages401-407
Number of pages7
ISBN (Print)3540615105, 9783540615101
DOIs
StatePublished - 1996
Event1996 International Conference on Artificial Neural Networks, ICANN 1996 - Bochum, Germany
Duration: 16 Jul 199619 Jul 1996

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1112 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1996 International Conference on Artificial Neural Networks, ICANN 1996
Country/TerritoryGermany
CityBochum
Period16/07/9619/07/96

Keywords

  • Laplace's Method
  • Markov Chain Monte Carlo Model Composition
  • Neural Networks
  • Nonhierarchical loglinear models

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