Detection of Au Nanoparticles Using Peptide-Modified Si3N4Nanopores

Abeer Karmi, Haya Dachlika, Gowri Priya Sakala, Dvir Rotem, Meital Reches*, Danny Porath*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Solid-state nanopores can be used as affordable and user-friendly detectors for biological molecules such as DNA, RNA, and proteins. Here, we used chemically modified silicon nitride nanopores to detect nanoparticles. The nanopores were modified with a peptide-based coating that significantly improved the pore current stability when compared to uncoated pores. The translocation of charged gold nanoparticles through the nanopore was characterized both for single particles (monomers) and for structures of two particles (dimers), connected by individual double-stranded DNA molecules. The monomers and dimers differ in their translocation time through the nanopore. The developed nanopore/nanoparticle-based system is a promising platform for the detection of DNA and other molecules for diagnostic purposes.

Original languageAmerican English
Pages (from-to)1000-1008
Number of pages9
JournalACS Applied Nano Materials
Volume4
Issue number2
DOIs
StatePublished - 26 Feb 2021

Bibliographical note

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Keywords

  • biomarkers
  • dimers
  • gold nanoparticles
  • nanopores
  • peptides

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