Detection of common motifs in RNA secondary structures

Hanah Margalit*, Bruce A. Shapiro, Amos B. Oppenheim, Jacob V. Maizel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

We describe a novel computerized system for comparison of RNA secondary structures and demonstrate its use for experimental studies. The system is able to screen a very large number of structures, to cluster similar structures and to detect specific structural motifs. In particular, the system is useful for detecting mutations with specific structural effects anong all possible point mutations, and for predicting compensatory mutations that will restore the wild type structure. The algorithms are independent of the folding rules that are used to generate the secondary structures.

Original languageAmerican English
Pages (from-to)4829-4845
Number of pages17
JournalNucleic Acids Research
Volume17
Issue number12
DOIs
StatePublished - 26 Jun 1989
Externally publishedYes

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