Detection of peptide-binding sites on protein surfaces using the peptimap server

Tanggis Bohnuud; George Jones; Ora Schueler-Furman; Dima Kozakov

doi:10.1007/978-1-4939-6798-8_2

Detection of peptide-binding sites on protein surfaces using the peptimap server

Tanggis Bohnuud, George Jones, Ora Schueler-Furman^*, Dima Kozakov

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Scopus citations

Abstract

Peptide-mediated interactions are of primordial importance to the cell, and the structure of such interaction provides an important starting point for their further characterization. In many cases, the structure of the peptide-protein complex has not been solved by experiment, and modeling tools need to be applied to generate structural models of the interaction. PeptiMap is a protocol that identifies the peptide-binding site when only the structure of the receptor is known, but no information about where the peptide binds is available. This is achieved by mapping the surface for solvents to identify ligand-binding sites, similar in approach to ANCHORMAP in which amino acids are mapped. Peptimap is a free open access web-based server. It can be accessed at http://peptimap.cluspro.org.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	11-20
Number of pages	10
DOIs	https://doi.org/10.1007/978-1-4939-6798-8_2
State	Published - 2017

Publication series

Name	Methods in Molecular Biology
Volume	1561
ISSN (Print)	1064-3745

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media LLC 2017.

Keywords

Binding site prediction
Peptide mapping
Peptide-protein interactions
Solvent mapping

Access to Document

10.1007/978-1-4939-6798-8_2

Cite this

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Detection of peptide-binding sites on protein surfaces using the peptimap server

Abstract

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Keywords

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