TY - JOUR
T1 - Detergent-resistant membranes should not be identified with membrane rafts
AU - Lichtenberg, Dov
AU - Goñi, Félix M.
AU - Heerklotz, Heiko
PY - 2005/8
Y1 - 2005/8
N2 - Three originally distinct concepts - lipid rafts, detergent-resistant membranes (DRMs) and liquid-ordered (lo) lipid phases - are often confused in current literature; many researchers have assumed that all three names refer to the same chemico-biological entity. In fact, theoretical and experimental findings provide strong evidence against identifying DRMs with rafts and lo domains. Because much of what we think we know about lipid rafts is based on their unjustified identification as DRMs, functional domains in biological membranes might differ markedly from the generally accepted picture.
AB - Three originally distinct concepts - lipid rafts, detergent-resistant membranes (DRMs) and liquid-ordered (lo) lipid phases - are often confused in current literature; many researchers have assumed that all three names refer to the same chemico-biological entity. In fact, theoretical and experimental findings provide strong evidence against identifying DRMs with rafts and lo domains. Because much of what we think we know about lipid rafts is based on their unjustified identification as DRMs, functional domains in biological membranes might differ markedly from the generally accepted picture.
UR - https://www.scopus.com/pages/publications/22744437388
U2 - 10.1016/j.tibs.2005.06.004
DO - 10.1016/j.tibs.2005.06.004
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 15996869
AN - SCOPUS:22744437388
SN - 0968-0004
VL - 30
SP - 430
EP - 436
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 8
ER -