TY - JOUR
T1 - Development of leptin antagonists and their potential use in experimental biology and medicine
AU - Gertler, Arieh
PY - 2006/11
Y1 - 2006/11
N2 - Leptin is a pleotropic hormone that acts both centrally and peripherally. Whereas leptin exhibits positive effects on several physiological functions, such as regulation of energy metabolism, reproductive function and immune responses, negative actions, such as enhancement of undesired immune responses in autoimmune diseases, tumorigenesis, elevated blood pressure and cardiovascular pathologies, have also been documented. The recent development of leptin muteins with antagonistic properties and other proteins that block leptin activity opens up new possibilities for their use in research and, eventually, therapy.
AB - Leptin is a pleotropic hormone that acts both centrally and peripherally. Whereas leptin exhibits positive effects on several physiological functions, such as regulation of energy metabolism, reproductive function and immune responses, negative actions, such as enhancement of undesired immune responses in autoimmune diseases, tumorigenesis, elevated blood pressure and cardiovascular pathologies, have also been documented. The recent development of leptin muteins with antagonistic properties and other proteins that block leptin activity opens up new possibilities for their use in research and, eventually, therapy.
UR - http://www.scopus.com/inward/record.url?scp=33750043782&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2006.09.006
DO - 10.1016/j.tem.2006.09.006
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C2 - 17010639
AN - SCOPUS:33750043782
SN - 1043-2760
VL - 17
SP - 372
EP - 378
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 9
ER -