Development of the gonadotropin-releasing hormone system

Anne H. Duittoz; Paolo E. Forni; Paolo Giacobini; Matan Golan; Patrice Mollard; Ariel L. Negrón; Sally Radovick; Susan Wray

doi:10.1111/jne.13087

Development of the gonadotropin-releasing hormone system

Anne H. Duittoz
, Paolo E. Forni
, Paolo Giacobini
, Matan Golan
, Patrice Mollard
, Ariel L. Negrón
, Sally Radovick
, Susan Wray^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

40 Scopus citations

Abstract

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

Original language	English
Article number	e13087
Journal	Journal of Neuroendocrinology
Volume	34
Issue number	5
DOIs	https://doi.org/10.1111/jne.13087
State	Published - May 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Keywords

GnRH
development
guidance cues
migratory pathway
olfactory ensheathing cells
olfactory placode
synaptic and paracrine signals
terminal nerve
transcription factors

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10.1111/jne.13087

Cite this

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title = "Development of the gonadotropin-releasing hormone system",

abstract = "This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.",

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AU - Mollard, Patrice

AU - Negrón, Ariel L.

AU - Radovick, Sally

AU - Wray, Susan

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KW - guidance cues

KW - migratory pathway

KW - olfactory ensheathing cells

KW - olfactory placode

KW - synaptic and paracrine signals

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Development of the gonadotropin-releasing hormone system

Abstract

Bibliographical note

Keywords

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