Developmental regulation of DNA replication timing at the human β globin locus

Itamar Simon, Toyoaki Tenzen, Raul Mostoslavsky, Eitan Fibach, Laura Lande, Eric Milot, Joost Gribnau, Frank Grosveld, Peter Fraser, Howard Cedar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


The human β globin locus replicates late in most cell types, but becomes early replicating in erythroid cells. Using FISH to map DNA replication timing around the endogenous β globin locus and by applying a genetic approach in transgenic mice, we have demonstrated that both the late and early replication states are controlled by regulatory elements within the locus control region. These results also show that the pattern of replication timing is set up by mechanisms that work independently of gene transcription.

Original languageAmerican English
Pages (from-to)6150-6157
Number of pages8
JournalEMBO Journal
Issue number21
StatePublished - 1 Nov 2001


  • LCR
  • Replication timing
  • β globin


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