Developmental regulation of immune system gene rearrangement

Howard Cedar*, Yehudit Bergman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.

Original languageAmerican English
Pages (from-to)64-69
Number of pages6
JournalCurrent Opinion in Immunology
Issue number1
StatePublished - 1 Feb 1999
Externally publishedYes

Bibliographical note

Funding Information:
We thank Raul Mostoslavsky for his help throughout the preparation of this review, and P Engler and Y Xu for providing information prior to publication. This research was supported by grants from the Israel Science Foundation (YB and HC), the German-Israeli Foundation for Scientific Research and Development (YB), the Israel Cancer Association (YB), the National Institutes of Health (HC) and the Israel Cancer Research Fund (HC).


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