Developmental regulation of immune system gene rearrangement

Howard Cedar; Yehudit Bergman

doi:10.1016/S0952-7915(99)80012-0

Developmental regulation of immune system gene rearrangement

Howard Cedar^*, Yehudit Bergman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.

Original language	American English
Pages (from-to)	64-69
Number of pages	6
Journal	Current Opinion in Immunology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/S0952-7915(99)80012-0
State	Published - 1 Feb 1999
Externally published	Yes

Bibliographical note

Funding Information:
We thank Raul Mostoslavsky for his help throughout the preparation of this review, and P Engler and Y Xu for providing information prior to publication. This research was supported by grants from the Israel Science Foundation (YB and HC), the German-Israeli Foundation for Scientific Research and Development (YB), the Israel Cancer Association (YB), the National Institutes of Health (HC) and the Israel Cancer Research Fund (HC).

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author = "Howard Cedar and Yehudit Bergman",

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Developmental regulation of immune system gene rearrangement

Abstract

Bibliographical note

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