Abstract
Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.
| Original language | English |
|---|---|
| Pages (from-to) | 64-69 |
| Number of pages | 6 |
| Journal | Current Opinion in Immunology |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Feb 1999 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Raul Mostoslavsky for his help throughout the preparation of this review, and P Engler and Y Xu for providing information prior to publication. This research was supported by grants from the Israel Science Foundation (YB and HC), the German-Israeli Foundation for Scientific Research and Development (YB), the Israel Cancer Association (YB), the National Institutes of Health (HC) and the Israel Cancer Research Fund (HC).
Fingerprint
Dive into the research topics of 'Developmental regulation of immune system gene rearrangement'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver