TY - JOUR
T1 - Dexanabinol; a novel neuroprotective drug in experimental focal cerebral ischemia
AU - Leker, Ronen R.
AU - Shohami, Esther
AU - Abramsky, Oded
AU - Ovadia, Haim
PY - 1999/1/15
Y1 - 1999/1/15
N2 - The permanent middle cerebral artery occlusion (PMCAO) model was used to investigate the cerebroprotective effects of the synthetic cannabinoid, dexanabinol (HU-211). Dexanabinol is a noncompetitive N-methyl-D-aspartate antagonist, with antioxidant and anti-TNFα properties. Twenty hypertensive rats were subjected to PMCAO. Eight were given 4 mg/kg dexanabinol, i.v, 1 h after PMCAO, eight received vehicle and four were not injected. Five rats underwent sham surgery. Infarct volumes were assessed, as well as TNFα concentrations and NOS activity in brain homogenates. Dexanabinol significantly decreased infarct volumes. It also significantly lowered TNFα levels in the ipsilateral hemisphere although not to the level of sham operated rats. No effect could be demonstrated on NOS activity. In conclusion, dexanabinol may be a pluripotent cerebroprotective agent.
AB - The permanent middle cerebral artery occlusion (PMCAO) model was used to investigate the cerebroprotective effects of the synthetic cannabinoid, dexanabinol (HU-211). Dexanabinol is a noncompetitive N-methyl-D-aspartate antagonist, with antioxidant and anti-TNFα properties. Twenty hypertensive rats were subjected to PMCAO. Eight were given 4 mg/kg dexanabinol, i.v, 1 h after PMCAO, eight received vehicle and four were not injected. Five rats underwent sham surgery. Infarct volumes were assessed, as well as TNFα concentrations and NOS activity in brain homogenates. Dexanabinol significantly decreased infarct volumes. It also significantly lowered TNFα levels in the ipsilateral hemisphere although not to the level of sham operated rats. No effect could be demonstrated on NOS activity. In conclusion, dexanabinol may be a pluripotent cerebroprotective agent.
KW - Dexanabinol
KW - Ischemia
KW - Nitric oxide synthase
KW - Stroke
KW - TNFα
UR - http://www.scopus.com/inward/record.url?scp=0033556581&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(98)00301-3
DO - 10.1016/S0022-510X(98)00301-3
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 10202976
AN - SCOPUS:0033556581
SN - 0022-510X
VL - 162
SP - 114
EP - 119
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 2
ER -
