TY - JOUR
T1 - DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response
AU - Granot, Esther
AU - Jakobovich, Einat
AU - Rabinowitz, Ruth
AU - Levy, Paloma
AU - Schlesinger, Michael
PY - 2011
Y1 - 2011
N2 - Background. It is currently recommended that diet of pregnant mothers contain 200-300 mgDHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods. 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. Results. CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (nave cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFN significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. Conclusions. In infants of mothers receiving DHA supplementation, a higher percentage of CD4 nave cells and decreased CD4 and CD8 IFN production is compatible with attenuation of a proinflammatory response.
AB - Background. It is currently recommended that diet of pregnant mothers contain 200-300 mgDHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods. 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. Results. CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (nave cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFN significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. Conclusions. In infants of mothers receiving DHA supplementation, a higher percentage of CD4 nave cells and decreased CD4 and CD8 IFN production is compatible with attenuation of a proinflammatory response.
UR - http://www.scopus.com/inward/record.url?scp=81555229381&partnerID=8YFLogxK
U2 - 10.1155/2011/493925
DO - 10.1155/2011/493925
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 21941411
AN - SCOPUS:81555229381
SN - 0962-9351
VL - 2011
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 493925
ER -