Dichotomous activity and function of neurons with low- and high-frequency discharge in the external globus pallidus of non-human primates

Shiran Katabi*, Avital Adler, Marc Deffains, Hagai Bergman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

To date, there is a consensus that there are at least two neuronal populations in the non-human primate (NHP) external globus pallidus (GPe): low-frequency discharge (LFD) and high-frequency discharge (HFD) neurons. Nevertheless, almost all NHP physiological studies have neglected the functional importance of LFD neurons. This study examined the discharge features of these two GPe neuronal subpopulations recorded in four NHPs engaged in a classical conditioning task with cues predicting reward, neutral and aversive outcomes. The results show that LFD neurons tended to burst, encoded the salience of behavioral cues, and exhibited correlated spiking activity. By contrast, the HFD neurons tended to pause, encoded cue valence, and exhibited uncorrelated spiking activity. Overall, these findings point to the dichotomic organization of the NHP GPe, which is likely to be critical to the implementation of normal basal ganglia functions and computations.

Original languageAmerican English
Article number111898
JournalCell Reports
Volume42
Issue number1
DOIs
StatePublished - 31 Jan 2023

Bibliographical note

Publisher Copyright:
© 2022 The Authors

Keywords

  • CP: Neuroscience
  • basal ganglia
  • behavior
  • dichotomous organization
  • electrophysiology
  • globus pallidus
  • information processing
  • non-human primates
  • single-unit recordings

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