TY - JOUR
T1 - Dietary persimmon improves lipid metabolism in rats fed diets containing cholesterol
AU - Gorinstein, Shela
AU - Bartnikowska, Elzbieta
AU - Kulasek, Gustaw
AU - Zemser, Marina
AU - Trakhtenberg, Simon
PY - 1998/11
Y1 - 1998/11
N2 - The effect of dietary persimmon (Pers, 7.0%) on lipid metabolism and antioxidant activity was investigated in 40 male Wistar rats adapted to cholesterol-free or 1% cholesterol diets. The rats were divided in four groups of 10. The basal diet contained wheat starch, casein, soybean oil, and mineral and vitamin mixtures. The control group (C) consumed the basal diet. To the basal diet were added 7 g/100 g dry persimmon (Pers), 1 g/100 g cholesterol (Chol), or both (Chol/Pers). The experiment lasted 4 wk. Plasma total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglycerides (TG), total phospholipids (TPH), HDL phospholipids (HDL-PH), lipid peroxides (LP) and liver TC concentrations were measured. Groups did not differ before the experiment. In the Chol/Pers vs. Chol group, the persimmon-supplemented diet significantly (P < 0.05) lessened the rise in plasma lipids due to dietary cholesterol: TC (3.88 vs. 4.88 mmol/L; -20%), LDL-C (2.24 vs. 3.27 mmol/L; -31%), TG (0.72 vs. 0.89 mmol/L; -19%), LP (2.20 vs. 3.25 mmol/L; -32%) and TC in liver (32.8 vs. 49.9 μmol/g; -34%), (P < 0.001). The Chol/Pers diet significantly reduced the decrease in HDL-PH due to dietary cholesterol (0.73 vs. 0.58 mmol/L; -25.8%, P < 0.001) and decreased the level of TPH (1.32 vs. 1.73 mmol/L; -23%, P < 0.001). Persimmon in rats fed the basal diet without cholesterol did not significantly affect the variables measured. These results demonstrate that persimmon possesses hypolipidemic and antioxidant properties that are evident when persimmon is added to the diet of rats fed cholesterol. These properties are attributed to its water-soluble dietary fiber, carotenoids and polyphenols.
AB - The effect of dietary persimmon (Pers, 7.0%) on lipid metabolism and antioxidant activity was investigated in 40 male Wistar rats adapted to cholesterol-free or 1% cholesterol diets. The rats were divided in four groups of 10. The basal diet contained wheat starch, casein, soybean oil, and mineral and vitamin mixtures. The control group (C) consumed the basal diet. To the basal diet were added 7 g/100 g dry persimmon (Pers), 1 g/100 g cholesterol (Chol), or both (Chol/Pers). The experiment lasted 4 wk. Plasma total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triglycerides (TG), total phospholipids (TPH), HDL phospholipids (HDL-PH), lipid peroxides (LP) and liver TC concentrations were measured. Groups did not differ before the experiment. In the Chol/Pers vs. Chol group, the persimmon-supplemented diet significantly (P < 0.05) lessened the rise in plasma lipids due to dietary cholesterol: TC (3.88 vs. 4.88 mmol/L; -20%), LDL-C (2.24 vs. 3.27 mmol/L; -31%), TG (0.72 vs. 0.89 mmol/L; -19%), LP (2.20 vs. 3.25 mmol/L; -32%) and TC in liver (32.8 vs. 49.9 μmol/g; -34%), (P < 0.001). The Chol/Pers diet significantly reduced the decrease in HDL-PH due to dietary cholesterol (0.73 vs. 0.58 mmol/L; -25.8%, P < 0.001) and decreased the level of TPH (1.32 vs. 1.73 mmol/L; -23%, P < 0.001). Persimmon in rats fed the basal diet without cholesterol did not significantly affect the variables measured. These results demonstrate that persimmon possesses hypolipidemic and antioxidant properties that are evident when persimmon is added to the diet of rats fed cholesterol. These properties are attributed to its water-soluble dietary fiber, carotenoids and polyphenols.
KW - Lipid peroxides
KW - Lipoproteins
KW - Persimmon
KW - Phospholipids
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=0031794161&partnerID=8YFLogxK
U2 - 10.1093/jn/128.11.2023
DO - 10.1093/jn/128.11.2023
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 9808659
AN - SCOPUS:0031794161
SN - 0022-3166
VL - 128
SP - 2023
EP - 2027
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 11
ER -