TY - JOUR
T1 - Diethystilbesterol counteracts barbiturate narcosis and hypothermia in Male mice
AU - Fishman, Rachelle H.B.
AU - Feigenbaum, Jefferey J.
AU - Iser-Strenger, Carmela
AU - Yanai, Joseph
PY - 1987
Y1 - 1987
N2 - Treatment with DES one hour prior to pentobarbital injection resulted in diminution of the narcotic sleep and hypothermia usually found after pentobarbital (50 mg/kg-1) injection in male mice. The effect was biphasic: significantly countered relative to saline pretreated controls at low (.001 -.10 mg/kg-1) and at high 10-50 mg/kg-1) DES doses only. Giving DES alone did not change core body temperature compared to saline injected controls, at either 25°C or at 33°F. At 33°C. neither PeB narcosis nor body temperature loss was significantly inhihited hy DES. Possible cytoplasmic. nonsex differentiated bases for these cstrogen cffccts on harhiturate action in the hrain is discussed.
AB - Treatment with DES one hour prior to pentobarbital injection resulted in diminution of the narcotic sleep and hypothermia usually found after pentobarbital (50 mg/kg-1) injection in male mice. The effect was biphasic: significantly countered relative to saline pretreated controls at low (.001 -.10 mg/kg-1) and at high 10-50 mg/kg-1) DES doses only. Giving DES alone did not change core body temperature compared to saline injected controls, at either 25°C or at 33°F. At 33°C. neither PeB narcosis nor body temperature loss was significantly inhihited hy DES. Possible cytoplasmic. nonsex differentiated bases for these cstrogen cffccts on harhiturate action in the hrain is discussed.
KW - Burbilurure nurcosis
KW - DES
KW - Hypothermia
UR - http://www.scopus.com/inward/record.url?scp=0023282613&partnerID=8YFLogxK
U2 - 10.3109/00207458709043339
DO - 10.3109/00207458709043339
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C2 - 3036728
AN - SCOPUS:0023282613
SN - 0020-7454
VL - 32
SP - 845
EP - 852
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 3-4
ER -