TY - JOUR
T1 - Differences in EBV receptor concentration between in vitro EBV‐converted lymphoma sublines reflect biological differences between the converting viral substrains
AU - Klein, George
AU - Manneborg, Agneta
AU - Steinitz, Michael
PY - 1979/2/15
Y1 - 1979/2/15
N2 - We have compared the EBV‐receptor concentration of two originally EBV‐negattve human B‐cell lymphoma lines, after in vitro conversion with the transforming B95‐8 or the cytopathic P3HR‐1 EB‐viral substrain, respectively, into permanent EBV‐carrying sublines. Receptors were measured by the quantitative EBV‐absorption bioassay of Sairenji and Hinuma (1973). EBV receptor concentration of all P3HR‐1 virus‐converted sublines was significantly reduced, in comparison with the B95‐8 virus‐converted sublines. This suggests that cells with a low receptor concentration are more likely to survive the initial infection with the P3HR‐1 viral harvest. The results further confirm the biological differences between the two EBV substrains.
AB - We have compared the EBV‐receptor concentration of two originally EBV‐negattve human B‐cell lymphoma lines, after in vitro conversion with the transforming B95‐8 or the cytopathic P3HR‐1 EB‐viral substrain, respectively, into permanent EBV‐carrying sublines. Receptors were measured by the quantitative EBV‐absorption bioassay of Sairenji and Hinuma (1973). EBV receptor concentration of all P3HR‐1 virus‐converted sublines was significantly reduced, in comparison with the B95‐8 virus‐converted sublines. This suggests that cells with a low receptor concentration are more likely to survive the initial infection with the P3HR‐1 viral harvest. The results further confirm the biological differences between the two EBV substrains.
UR - http://www.scopus.com/inward/record.url?scp=0018346350&partnerID=8YFLogxK
U2 - 10.1002/ijc.2910230210
DO - 10.1002/ijc.2910230210
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C2 - 216641
AN - SCOPUS:0018346350
SN - 0020-7136
VL - 23
SP - 197
EP - 200
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 2
ER -