TY - JOUR
T1 - Differences in outcomes over time with exclusive enteral nutrition compared with steroids in children with mild to moderate Crohn's disease
T2 - Results from the GROWTH CD study
AU - Cohen-Dolev, Noa
AU - Sladek, Malgorata
AU - Hussey, Seamus
AU - Turner, Dan
AU - Veres, Gabor
AU - Koletzko, Sibylle
AU - de Carpi, Javier Martin
AU - Staiano, Annamaria
AU - Shaoul, Ron
AU - Lionetti, Paolo
AU - Dias, Jorge Amil
AU - Paerregaard, Anders
AU - Nuti, Federica
AU - Gik, Tamar Pfeffer
AU - Ziv-Baran, Tomer
AU - Shulman, Sivan Ben Avraham
AU - Shabat, Chen Sarbagili
AU - Boneh, Rotem Sigall
AU - Russell, Richard K.
AU - Levinea, Arie
N1 - Publisher Copyright:
© 2016 European Crohn's and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved.
PY - 2018/2/28
Y1 - 2018/2/28
N2 - Background: Exclusive enteral nutrition [EEN] and corticosteroids [CS] induce similar rates of remission in mild to moderate paediatric Crohn's disease [CD], but differ with regard to mucosal healing. Our goal was to evaluate if EEN at diagnosis was superior to CS for improving long-term outcomes. Methods: We prospectively followed newly diagnosed children aged < 17 years, with mild to moderate CD at baseline, for 2 years in the GROWTH CD study. Patients were evaluated at baseline and at 8, 12, 78, and 104 weeks. Remission, relapses, complications [fibrostenotic disease, penetrating disease, and active perianal disease] and growth were recorded throughout the study. A propensity score analysis was performed. Results: A total of 147 children [mean age 12.9 ± 3.2 years], treated by EEN [n = 60] or CS [n = 87] were included. New complications developed in 13.7% of CS [12/87] versus 11.6% of EEN [7/60], p = 0.29. Remission was achieved in 41/87 [47%] in CS and 38/60 [63%] EEN, p = 0.036. Median time to relapse did not differ [14.4 ± 1 months with CS, 16.05 ± 1.1 EEN, p = 0.28]. Mean height Z scores decreased from Week 0 to Week 78 with CS [-0.34 ± 1.1 to -0.51 ± 1.2, p = 0.01], but not with EEN [-0.32 ± 1.1 to -0.22 ± 0.9, p = 0.56]. In a propensity score analysis, EEN was superior to CS for inducing remission [p = 0.05] and trended to superiority for height Z score [p = 0.055]. Conclusions: Use of EEN was associated with higher remission rates and a trend toward better growth but with similar relapse and complication rates in new-onset mild to moderate paediatric CD.
AB - Background: Exclusive enteral nutrition [EEN] and corticosteroids [CS] induce similar rates of remission in mild to moderate paediatric Crohn's disease [CD], but differ with regard to mucosal healing. Our goal was to evaluate if EEN at diagnosis was superior to CS for improving long-term outcomes. Methods: We prospectively followed newly diagnosed children aged < 17 years, with mild to moderate CD at baseline, for 2 years in the GROWTH CD study. Patients were evaluated at baseline and at 8, 12, 78, and 104 weeks. Remission, relapses, complications [fibrostenotic disease, penetrating disease, and active perianal disease] and growth were recorded throughout the study. A propensity score analysis was performed. Results: A total of 147 children [mean age 12.9 ± 3.2 years], treated by EEN [n = 60] or CS [n = 87] were included. New complications developed in 13.7% of CS [12/87] versus 11.6% of EEN [7/60], p = 0.29. Remission was achieved in 41/87 [47%] in CS and 38/60 [63%] EEN, p = 0.036. Median time to relapse did not differ [14.4 ± 1 months with CS, 16.05 ± 1.1 EEN, p = 0.28]. Mean height Z scores decreased from Week 0 to Week 78 with CS [-0.34 ± 1.1 to -0.51 ± 1.2, p = 0.01], but not with EEN [-0.32 ± 1.1 to -0.22 ± 0.9, p = 0.56]. In a propensity score analysis, EEN was superior to CS for inducing remission [p = 0.05] and trended to superiority for height Z score [p = 0.055]. Conclusions: Use of EEN was associated with higher remission rates and a trend toward better growth but with similar relapse and complication rates in new-onset mild to moderate paediatric CD.
KW - Child
KW - Complications
KW - Crohn
KW - Diet
KW - Enteral nutrition
KW - Growth
KW - Inflammatory bowel disease
KW - Relapse
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=85046124682&partnerID=8YFLogxK
U2 - 10.1093/ecco-jcc/jjx150
DO - 10.1093/ecco-jcc/jjx150
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 29165666
AN - SCOPUS:85046124682
SN - 1873-9946
VL - 12
SP - 306
EP - 312
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 3
ER -