Differential accessibility at the κ chain locus plays a role in allelic exclusion

Maya Goldmit, Mark Schlissel, Howard Cedar, Yehudit Bergman

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin κ locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition, serves as the basis for allelic exclusion.

Original languageEnglish
Pages (from-to)5255-5261
Number of pages7
JournalEMBO Journal
Volume21
Issue number19
DOIs
StatePublished - 1 Oct 2002

Keywords

  • Chromatin
  • DNA methylation
  • DNase I sensitivity
  • Double strand breaks
  • V(D)J rearrangement

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