Differentiation of stable kidney function versus progressive dysfunction in dogs

Larry D. Cowgill*, Gilad Segev, Shelly Vaden, Sheri Ross, Cedric Dufayet, Leah A. Cohn, Mary Nabity, Giosi Farace, Donald Szlosek, Zenhwa Ouyang, Sarah Peterson, Melissa Beall, Murthy Yerramilli, David Polzin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine−1 or SDMA−1) has shown promise, but quantitative criteria to distinguish stable vs progressive CKD using this approach are lacking. Objective: Assessment of creatinine−1 and SDMA−1 slope cutoffs to distinguish stable vs progressive CKD. Animals: One hundred ten clinically healthy university staff-owned dogs and 29 male colony dogs with progressive X-linked hereditary nephropathy (XLHN). Methods: Retrospective analysis combining 2 prospective observational studies, 1 tracking kidney function biomarkers in healthy dogs (HDs) to a maximum of 3 years, and 1 tracking kidney function biomarkers in male colony dogs with progressive XLHN to a maximum of 1 year. The minimum slope of creatinine−1 or SDMA−1 as measured using the IDEXX SDMA test from HD was assigned as the slope cutoff for stable kidney function. Results: The stable vs progressive slope cutoff was −0.0119 week × dL/mg for creatinine−1 and −0.0007 week × dL/μg for SDMA−1. Conclusions and Clinical Importance: In the studied CKD population, progressive dysfunction can be distinguished from stable kidney function by using the slope of creatinine−1 or SDMA−1. These criteria may serve to characterize CKD in other cohorts of dogs and to establish guidelines for degrees of progression rate in dogs with naturally occurring CKD.

Original languageAmerican English
Pages (from-to)2241-2250
Number of pages10
JournalJournal of Veterinary Internal Medicine
Issue number6
StatePublished - 1 Nov 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.


  • biomarker
  • creatinine
  • disease monitoring
  • inverse slope
  • symmetric dimethylarginine


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