Abstract
In the present work we show that diffusion cannot provide the observed fast discharge of neurotransmitter from a synaptic vesicle during neurotransmitter release, mainly because it is not sufficiently rapid nor is it sufficiently temperature-dependent. Modeling the discharge from the vesicle into the cleft as a continuous point source, we have determined that discharge should occur in 50–75 microseconds, to provide the observed high concentrations of transmitter at the critical zone.
Original language | English |
---|---|
Pages (from-to) | 966-972 |
Number of pages | 7 |
Journal | Biophysical Journal |
Volume | 67 |
Issue number | 3 |
DOIs | |
State | Published - 1994 |
Externally published | Yes |