Diffusion of drugs through multibarrier

M. Friedman*, M. Donbrow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Diffusional mass transfer across a serial 2 or 3 unit laminate barrier of ethyl cellulose and polyethylene glycol membranes was studied using caffeine and salicylic acid as model drugs. The overall membrane diffusional resistance was found to be the sum of the intrinsic membrane resistances. When the resistance of one layer was much higher than that of the others, the permeability was then controlled by the single layer in the laminate.

Original languageEnglish
Pages (from-to)1417-1420
Number of pages4
JournalInternational Journal of Clinical Pharmacy
Volume2
Issue number1
DOIs
StatePublished - Dec 1980

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