Diffusion of drugs through multibarrier

M. Friedman; M. Donbrow

doi:10.1007/BF02273356

Diffusion of drugs through multibarrier

M. Friedman^*
, M. Donbrow

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Diffusional mass transfer across a serial 2 or 3 unit laminate barrier of ethyl cellulose and polyethylene glycol membranes was studied using caffeine and salicylic acid as model drugs. The overall membrane diffusional resistance was found to be the sum of the intrinsic membrane resistances. When the resistance of one layer was much higher than that of the others, the permeability was then controlled by the single layer in the laminate.

Original language	English
Pages (from-to)	1417-1420
Number of pages	4
Journal	Pharmaceutisch Weekblad - Scientific Edition
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/BF02273356
State	Published - Dec 1980

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10.1007/BF02273356

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title = "Diffusion of drugs through multibarrier",

abstract = "Diffusional mass transfer across a serial 2 or 3 unit laminate barrier of ethyl cellulose and polyethylene glycol membranes was studied using caffeine and salicylic acid as model drugs. The overall membrane diffusional resistance was found to be the sum of the intrinsic membrane resistances. When the resistance of one layer was much higher than that of the others, the permeability was then controlled by the single layer in the laminate.",

author = "M. Friedman and M. Donbrow",

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AB - Diffusional mass transfer across a serial 2 or 3 unit laminate barrier of ethyl cellulose and polyethylene glycol membranes was studied using caffeine and salicylic acid as model drugs. The overall membrane diffusional resistance was found to be the sum of the intrinsic membrane resistances. When the resistance of one layer was much higher than that of the others, the permeability was then controlled by the single layer in the laminate.

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Diffusion of drugs through multibarrier

Abstract

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