Diffusion of peptides through hydrogel membranes

Abraham Domb; G. W.Raymond Davidson; Lynda M. Sanders

doi:10.1016/0168-3659(90)90150-R

Diffusion of peptides through hydrogel membranes

Abraham Domb
, G. W.Raymond Davidson
, Lynda M. Sanders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.

Original language	English
Pages (from-to)	133-144
Number of pages	12
Journal	Journal of Controlled Release
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0168-3659(90)90150-R
State	Published - Oct 1990
Externally published	Yes

Keywords

hydration
hydrogel membranes
luteinizing hormone releasing hormone
nafaralin
poly(hydroxyalkyl methacrylate)

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10.1016/0168-3659(90)90150-R

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title = "Diffusion of peptides through hydrogel membranes",

abstract = "Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31\% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.",

keywords = "hydration, hydrogel membranes, luteinizing hormone releasing hormone, nafaralin, poly(hydroxyalkyl methacrylate)",

author = "Abraham Domb and Davidson, \{G. W.Raymond\} and Sanders, \{Lynda M.\}",

year = "1990",

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doi = "10.1016/0168-3659(90)90150-R",

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T1 - Diffusion of peptides through hydrogel membranes

AU - Domb, Abraham

AU - Davidson, G. W.Raymond

AU - Sanders, Lynda M.

PY - 1990/10

Y1 - 1990/10

N2 - Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.

AB - Diffusion of four decapeptides (LHRH analogs) through glycerol methacrylate, hydroxyethyl methacrylate, and hydroxyethyl methacrylate-co-methyl methacrylate hydrogels was studied, and the results compared with theory. Polymer films were prepared both by film casting from a monomer solution and by in situ polymerization. For membranes with high water content (≥ 31% w/w), permeability was found to vary exponentially with the reciprocal of the degree of hydration of the membrane, as predicted by an analysis based on free volume theory.

KW - hydration

KW - hydrogel membranes

KW - luteinizing hormone releasing hormone

KW - nafaralin

KW - poly(hydroxyalkyl methacrylate)

UR - https://www.scopus.com/pages/publications/0025096443

U2 - 10.1016/0168-3659(90)90150-R

DO - 10.1016/0168-3659(90)90150-R

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 2

ER -

Diffusion of peptides through hydrogel membranes

Abstract

Keywords

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