TY - JOUR
T1 - Dimers as Intermediates in the Assembly of Tetrameric Proteins
T2 - A Study on Lactate Dehydrogenase Isozymes
AU - Levitzki, Alexander
AU - Tenenbaum, Hana
PY - 1974
Y1 - 1974
N2 - The renaturation kinetics of pig heart, pig muscle, beef heart and beef muscle lactic dehydrogenases was studied. It was found that in all four cases the major intermediate in the assembly process is a lactate dehydrogenase dimer. It was found that NAD+ and NADH influence dramatically the kinetics of renaturation, probably by binding to a partially refolded subunit prior to the assembly to the fully renatured tetramer.
AB - The renaturation kinetics of pig heart, pig muscle, beef heart and beef muscle lactic dehydrogenases was studied. It was found that in all four cases the major intermediate in the assembly process is a lactate dehydrogenase dimer. It was found that NAD+ and NADH influence dramatically the kinetics of renaturation, probably by binding to a partially refolded subunit prior to the assembly to the fully renatured tetramer.
UR - http://www.scopus.com/inward/record.url?scp=84987313515&partnerID=8YFLogxK
U2 - 10.1002/ijch.197400026
DO - 10.1002/ijch.197400026
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:84987313515
SN - 0021-2148
VL - 12
SP - 327
EP - 337
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 1-2
ER -