Diols as effective oocatalysts in the phase transfer catalyzed preparation of 1-alkynes from 1,2-dihalides

Eckehard V. Dehmlow*, Rainer Thieser, Yoel Sasson, Ronny Neumann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Bis-tertiary diols accelerate bis-eliminations of HX from 1,2-dihalides in the presence of an onium salt as phase transfer catalyst and potassium hydroxide as base. PEG 400 catalyzes the same elimination, but isomerizations from 1-alkyne to mixtures with the 2-alkyne and the 1,2-diene occur easily.

Original languageEnglish
Pages (from-to)3569-3574
Number of pages6
JournalTetrahedron
Volume42
Issue number13
DOIs
StatePublished - 1986

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