Dipeptide Nanotubes Containing Unnatural Fluorine-Substituted β2,3-Diarylamino Acid and l -Alanine as Candidates for Biomedical Applications

Andrea Bonetti, Sara Pellegrino*, Priyadip Das, Sivan Yuran, Raffaella Bucci, Nicola Ferri, Fiorella Meneghetti, Carlo Castellano, Meital Reches, Maria Luisa Gelmi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

The synthesis and the structural characterization of dipeptides composed of unnatural fluorine-substituted β2,3-diarylamino acid and l-alanine are reported. Depending on the stereochemistry of the β amino acid, these dipeptides are able to self-assemble into proteolytic stable nanotubes. These architectures were able to enter the cell and locate in the cytoplasmic/perinuclear region and represent interesting candidates for biomedical applications.

Original languageAmerican English
Pages (from-to)4468-4471
Number of pages4
JournalOrganic Letters
Volume17
Issue number18
DOIs
StatePublished - 18 Sep 2015

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

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