Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice

Eldad Melamed; Giora Martinovits; Eli Pikarsky; Jutta Rosenthal; Anat Uzzan

doi:10.1016/0014-2999(86)90773-9

Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice

Eldad Melamed^*, Giora Martinovits, Eli Pikarsky, Jutta Rosenthal, Anat Uzzan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The combined administration of MPTP with the anticonvulsant drugs diphenylhydantoin or phenobarbital suppressed the MPTP-induced striatal DA depletions in mice. Co-treatment with diazepam, sodium valproate or carbamazepine was ineffective. The mechanism responsible for the protective effect of diphenylhydantoin and phenobarbital against DA neurotoxicity of MPTP is unknown but some previously available findings suggest that they may act, in part, via inhibition of MAO-B and/or DA reuptake in the striatum.

Original language	English
Pages (from-to)	255-257
Number of pages	3
Journal	European Journal of Pharmacology
Volume	128
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(86)90773-9
State	Published - 9 Sep 1986
Externally published	Yes

Keywords

Carbamazepine
Diazepam
Diphenylhydantoin
Dopaminergic neurotoxicity
MPTP
Phenobarbital
Sodium valproate

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10.1016/0014-2999(86)90773-9

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title = "Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice",

abstract = "The combined administration of MPTP with the anticonvulsant drugs diphenylhydantoin or phenobarbital suppressed the MPTP-induced striatal DA depletions in mice. Co-treatment with diazepam, sodium valproate or carbamazepine was ineffective. The mechanism responsible for the protective effect of diphenylhydantoin and phenobarbital against DA neurotoxicity of MPTP is unknown but some previously available findings suggest that they may act, in part, via inhibition of MAO-B and/or DA reuptake in the striatum.",

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T1 - Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice

AU - Melamed, Eldad

AU - Martinovits, Giora

AU - Pikarsky, Eli

AU - Rosenthal, Jutta

AU - Uzzan, Anat

PY - 1986/9/9

Y1 - 1986/9/9

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AB - The combined administration of MPTP with the anticonvulsant drugs diphenylhydantoin or phenobarbital suppressed the MPTP-induced striatal DA depletions in mice. Co-treatment with diazepam, sodium valproate or carbamazepine was ineffective. The mechanism responsible for the protective effect of diphenylhydantoin and phenobarbital against DA neurotoxicity of MPTP is unknown but some previously available findings suggest that they may act, in part, via inhibition of MAO-B and/or DA reuptake in the striatum.

KW - Carbamazepine

KW - Diazepam

KW - Diphenylhydantoin

KW - Dopaminergic neurotoxicity

KW - MPTP

KW - Phenobarbital

KW - Sodium valproate

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JO - European Journal of Pharmacology

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ER -

Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice

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Keywords

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