TY - JOUR
T1 - Direct measurements on individual microcapsule dissolution as a tool for determination of release mechanism
AU - Hoffman, A.
AU - Donbrow, M.
AU - Benita, S.
PY - 1986/10
Y1 - 1986/10
N2 - A method is described for simultaneous microscopic observation of individual microcapsule core material dissolution together with quantitative measurement of the individual kinetics of release of the contents. These may be conductimetric in the case of ionized materials or spectro‐photometric otherwise. This enables correlation of changes in core surface area during dissolution with kinetics. Surprisingly, both ethyl cellulose‐ and polymethacrylatecoated cores of potassium dichromate crystals, used as a model, showed localized internal dissolution universally, providing evidence of the exit of the salt via pores in the membrane, in spite of the kinetics being invariably zero order, as expected for individual microcapsules. The advantages of the method are presented.
AB - A method is described for simultaneous microscopic observation of individual microcapsule core material dissolution together with quantitative measurement of the individual kinetics of release of the contents. These may be conductimetric in the case of ionized materials or spectro‐photometric otherwise. This enables correlation of changes in core surface area during dissolution with kinetics. Surprisingly, both ethyl cellulose‐ and polymethacrylatecoated cores of potassium dichromate crystals, used as a model, showed localized internal dissolution universally, providing evidence of the exit of the salt via pores in the membrane, in spite of the kinetics being invariably zero order, as expected for individual microcapsules. The advantages of the method are presented.
UR - http://www.scopus.com/inward/record.url?scp=0022558125&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1986.tb04487.x
DO - 10.1111/j.2042-7158.1986.tb04487.x
M3 - Article
C2 - 2878999
AN - SCOPUS:0022558125
SN - 0022-3573
VL - 38
SP - 764
EP - 766
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
IS - 10
ER -