Dirofilaria repens infection in a dog: Diagnosis and treatment with melarsomine and doramectin

Gad Baneth*, Zafrir Volansky, Yigal Anug, Guido Favia, Odile Bain, Richard E. Goldstein, Shimon Harrus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Therapy of canine dirofilariois due to Dirofilaria repens is indicated for dogs suffering from clinical signs of this disease, such as dermal swelling, sub-cutaneous nodules and pruritus. It is also important in order to decrease the risk of infection to other dogs and humans in the vicinity of the infected animal when suitable mosquito vectors are present. Combined therapy with the arsenic adulticide melarsomine and the avermectin microfilaricidal doramectin was effective in clearing infection with D. repens in a dog. The number of microfilariae dropped from 17μl-1 blood pre-treatment to 7μl-1 following the first adulticide injection and reached 0 a day after the microfilaricidal administration. The dog remained negative for D. repens microfilaremia during a follow-up period of 90 days. Euthanasia and necropsy performed 3 months after the initiation of therapy due to a progressive neoplastic disease revealed no evidence of filariae.

Original languageAmerican English
Pages (from-to)173-178
Number of pages6
JournalVeterinary Parasitology
Volume105
Issue number2
DOIs
StatePublished - 30 Apr 2002

Keywords

  • Dirofilaria repens
  • Dog
  • Doramectin
  • Melarsomine

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