Discrepancy between the development of tolerance to bupivacaine in extradural and spinal anaesthesia in rabbits

E. Golomb*, L. Langerman, S. Benita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We gave equal groups of rabbits seven extradural (500 μg kg-1 or intrathecal (250 μg kg-1 injections of bupivacaine, at 24-h intervals. A decrease in the duration of motor block was observed after the extradural injections. The intrathecal injections exerted a reproducible effect. An additional regimen was tested in which five doses of bupivacaine 125 μg kg-1 were administered intrathecally after a loading dose of 250 μg kg-1 when the animals showed partial recovery from the previous dose; there was no decrease in the effect. The absence of tolerance to intrathecal bupivacaine implies that tachyphylaxis to extradural local anaesthetics results from a decrease in availability of the drug to the neural target, rather than a diminution in effect at the site of action. (Br. J. Anaesth. 1993; 71: 450-452)

Original languageEnglish
Pages (from-to)450-452
Number of pages3
JournalBritish Journal of Anaesthesia
Volume71
Issue number3
DOIs
StatePublished - Sep 1993

Keywords

  • Anaesthetic techniques: spinal, extradural
  • Anaesthetics, local: bupivacaine
  • Tachyphylaxis

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