TY - JOUR
T1 - Discrepancy between the development of tolerance to bupivacaine in extradural and spinal anaesthesia in rabbits
AU - Golomb, E.
AU - Langerman, L.
AU - Benita, S.
PY - 1993/9
Y1 - 1993/9
N2 - We gave equal groups of rabbits seven extradural (500 μg kg-1 or intrathecal (250 μg kg-1 injections of bupivacaine, at 24-h intervals. A decrease in the duration of motor block was observed after the extradural injections. The intrathecal injections exerted a reproducible effect. An additional regimen was tested in which five doses of bupivacaine 125 μg kg-1 were administered intrathecally after a loading dose of 250 μg kg-1 when the animals showed partial recovery from the previous dose; there was no decrease in the effect. The absence of tolerance to intrathecal bupivacaine implies that tachyphylaxis to extradural local anaesthetics results from a decrease in availability of the drug to the neural target, rather than a diminution in effect at the site of action. (Br. J. Anaesth. 1993; 71: 450-452)
AB - We gave equal groups of rabbits seven extradural (500 μg kg-1 or intrathecal (250 μg kg-1 injections of bupivacaine, at 24-h intervals. A decrease in the duration of motor block was observed after the extradural injections. The intrathecal injections exerted a reproducible effect. An additional regimen was tested in which five doses of bupivacaine 125 μg kg-1 were administered intrathecally after a loading dose of 250 μg kg-1 when the animals showed partial recovery from the previous dose; there was no decrease in the effect. The absence of tolerance to intrathecal bupivacaine implies that tachyphylaxis to extradural local anaesthetics results from a decrease in availability of the drug to the neural target, rather than a diminution in effect at the site of action. (Br. J. Anaesth. 1993; 71: 450-452)
KW - Anaesthetic techniques: spinal, extradural
KW - Anaesthetics, local: bupivacaine
KW - Tachyphylaxis
UR - http://www.scopus.com/inward/record.url?scp=0027323577&partnerID=8YFLogxK
U2 - 10.1093/bja/71.3.450
DO - 10.1093/bja/71.3.450
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C2 - 8398532
AN - SCOPUS:0027323577
SN - 0007-0912
VL - 71
SP - 450
EP - 452
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 3
ER -